Mutualists and parasites: how to paint yourself into a (metabolic) corner

Publication Type:Journal Article
Year of Publication:2001
Authors:I. Tamas, Klasson, L. M., Sandstrom, J. P., Andersson, S. G.
Journal:FEBS letters
Volume:498
Issue:2-3
Pagination:135 - 139
Date Published:2001
ISBN Number:0014-5793
Keywords:adaptation, animals, Aphids/microbiology, Buchnera, Evolution, Molecular, genome, humans, Pediculus, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Rickettsia prowazekii/genetics/physiology, Symbiosis
Abstract:

Eukaryotes have developed an elaborate series of interactions with bacteria that enter their bodies and/or cells. Genome evolution of symbiotic and parasitic bacteria multiplying inside eukaryotic cells results in both convergent and divergent changes. The genome sequences of the symbiotic bacteria of aphids, Buchnera aphidicola, and the parasitic bacteria of body louse and humans, Rickettsia prowazekii, provide insights into these processes. Convergent genome characteristics include reduction in genome sizes and lowered G+C content values. Divergent evolution was recorded for amino acid and cell wall biosynthetic genes. The presence of pseudogenes in both genomes provides examples of recent gene inactivation events and offers clues to the process of genome deterioration and host-cell adaptation.

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Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith