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Treatment of head louse infestation with 4% dimeticone lotion: randomised controlled equivalence trial

Publication Type:Journal Article
Year of Publication:2005
Authors:I. F. Burgess, Brown, C. M., Lee, P. N.
Journal:British Medical Journal
Volume:330
Issue:7505
Pagination:1423 - 1426
Date Published:2005
ISBN Number:1468-5833
Keywords:Administration, Topical, adolescent, adult, animals, child, Child, Preschool, Follow-Up Studies, humans, insecticide, Lice Infestations/drug therapy, Pediculus, Pyrethrum, Research Support, Non-U.S. Gov't, scalp dermatoses, Siloxanes/administration & dosage, Treatment Outcome
Abstract:

OBJECTIVE: To evaluate the efficacy and safety of 4% dimeticone lotion for treatment of head louse infestation.DESIGN: Randomised controlled equivalence trial. SETTING: Community, with home visits. PARTICIPANTS: 214 young people aged 4 to 18 years and 39 adults with active head louse infestation. INTERVENTIONS: Two applications seven days apart of either 4.0% dimeticone lotion, applied for eight hours or overnight, or 0.5% phenothrin liquid, applied for 12 hours or overnight. OUTCOME MEASURES: Cure of infestation (no evidence of head lice after second treatment) or reinfestation after cure. RESULTS: Cure or reinfestation after cure occurred in 89 of 127 (70%) participants treated with dimeticone and 94 of 125 (75%) treated with phenothrin (difference -5%, 95% confidence interval -16% to 6%). Per protocol analysis showed that 84 of 121 (69%) participants were cured with dimeticone and 90 of 116 (78%) were cured with phenothrin. Irritant reactions occurred significantly less with dimeticone (3/127, 2%) than with phenothrin (11/125, 9%; difference -6%, -12% to -1%). Per protocol this was 3 of 121 (3%) participants treated with dimeticone and 10 of 116 (9%) treated with phenothrin (difference -6%, -12% to -0.3%). CONCLUSION: Dimeticone lotion cures head louse infestation. Dimeticone seems less irritant than existing treatments and has a physical action on lice that should not be affected by resistance to neurotoxic insecticides.

URL:http://www.phthiraptera.info/sites/phthiraptera.info/files/44641.pdf
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