Tumour necrosis factor, interleukin-6 and C-reactive protein in patients with louse-borne relapsing fever in Ethiopia

Publication Type:Journal Article
Year of Publication:1995
Authors:L. E. Cuevas, Borgnolo, G., Hailu, B., Smith, G., Almaviva, M., Hart, C. A.
Journal:Annals of Tropical Medicine and Parasitology
Pagination:49 - 54
Date Published:1995
ISBN Number:0003-4983
Keywords:adolescent, adult, animals, Borrelia, Chloramphenicol, Ethiopia, humans, Insect vectors, lice, Middle Aged, Relapsing Fever, Tetracycline/therapeutic use, Time Factors, tumor necrosis

The serum concentrations of tumour necrosis factor (TNF), interleukin-6 (IL-6) and C-reactive protein (CRP) were studied in 25 patients with louse-borne relapsing fever, to evaluate their association with the level of bacteraemia, anti-borrelia chemotherapy and the presence of a Jarish-Herxheimer reaction (JHR). Although there was an association between the level of bacteraemia and the development of JHR and complications during treatment, TNF, IL-6 and CRP concentrations were not associated with the JHR. TNF concentrations increased after the administration of antibiotics and remained high for 24 h. IL-6 was elevated on admission but soon decreased. CRP was high on admission and remained so throughout the illness. The observed elevations in TNF, IL-6 and CRP may be associated more with the administration of antibiotics than with the presence of a JHR.

Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith