• Upgraded to latest Scratchpad release 2.9.2

Ivermectin lipid-based nanocarriers as novel formulations against head lice

Publication Type:Journal Article
Year of Publication:2017
Authors:Ullio-Gamboa, G, Palma, S, Benoit, JPierre, Allemandi, D, Picollo, MInés, Toloza, ACeferino
Journal:Parasitology Research
Volume:116
Issue:8
Pagination:2111 - 2117
Date Published:Jan-08-2017
ISSN:0932-0113
Keywords:ivermectin, Lipid nanoparticles, Nanotechnology, pediculosis
Abstract:

The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of effi- ciently insecticide delivery systems is imperative for the con- trol of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, pre- pared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability. These nanoparticles were nearly spherical with mean diameters of 55 nm and narrow size distribution (PI ≤ 0.2). The KT50 mor- tality values of head lice after exposure to two IVM-LNC formulations (0.11 and 0.28%) were significantly smaller (5 and 3 h, respectively) compared to those exposed only to LNC control group (8 h). This investigation showed the effective- ness in the encapsulation of ivermectin (IVM) into stable LNC dispersion with a potential clinical activity against head lice.

URL:http://link.springer.com/10.1007/s00436-017-5510-2
DOI:10.1007/s00436-017-5510-2
Short Title:Parasitol Res
File attachments: 
Thu, 2018-10-11 17:01 -- Yokb
Scratchpads developed and conceived by (alphabetical): Ed Baker, Katherine Bouton Alice Heaton Dimitris Koureas, Laurence Livermore, Dave Roberts, Simon Rycroft, Ben Scott, Vince Smith