|Publication Type:||Journal Article|
|Year of Publication:||2017|
|Authors:||Ullio-Gamboa, G, Palma, S, Benoit, JPierre, Allemandi, D, Picollo, MInés, Toloza, ACeferino|
|Pagination:||2111 - 2117|
|Keywords:||ivermectin, Lipid nanoparticles, Nanotechnology, pediculosis|
The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of effi- ciently insecticide delivery systems is imperative for the con- trol of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, pre- pared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability. These nanoparticles were nearly spherical with mean diameters of 55 nm and narrow size distribution (PI ≤ 0.2). The KT50 mor- tality values of head lice after exposure to two IVM-LNC formulations (0.11 and 0.28%) were significantly smaller (5 and 3 h, respectively) compared to those exposed only to LNC control group (8 h). This investigation showed the effective- ness in the encapsulation of ivermectin (IVM) into stable LNC dispersion with a potential clinical activity against head lice.
|Short Title:||Parasitol Res|
Ivermectin lipid-based nanocarriers as novel formulations against head lice