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Ivermectin lipid-based nanocarriers as novel formulations against head lice

Publication Type:Journal Article
Year of Publication:2017
Authors:G. Ullio-Gamboa, Palma, S., Benoit, J. Pierre, Allemandi, D., Picollo, M. Inés, Toloza, A. Ceferino
Journal:Parasitology Research
Pagination:2111 - 2117
Date Published:Jan-08-2017
Keywords:ivermectin, Lipid nanoparticles, Nanotechnology, pediculosis

The use of pyrethroids to control the human head louse, Pediculus humanus capitis De Geer (Anoplura: Pediculidae), has suffered considerable loss of efficacy due to the evolution of resistance. Thus, the development of effi- ciently insecticide delivery systems is imperative for the con- trol of head lice. We studied the insecticidal activity of ivermectin-loaded lipid nanocapsules (IVM-LNC) against permethrin-resistant head lice from Argentina. The LNC, pre- pared by a phase inversion procedure, were characterized in terms of size, surface potential, and physical stability. These nanoparticles were nearly spherical with mean diameters of 55 nm and narrow size distribution (PI ≤ 0.2). The KT50 mor- tality values of head lice after exposure to two IVM-LNC formulations (0.11 and 0.28%) were significantly smaller (5 and 3 h, respectively) compared to those exposed only to LNC control group (8 h). This investigation showed the effective- ness in the encapsulation of ivermectin (IVM) into stable LNC dispersion with a potential clinical activity against head lice.

Short Title:Parasitol Res
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